The main difference between osteoblasts and osteoclasts is that osteoblasts are involved in bone formation and mineralization while osteoclasts are involved in the breakdown and resorption of bones. Osteogenic cells in bone are developed into osteoblasts.

Osteoblasts secrete collagen matrix and bone calcium salts. When osteoblasts are trapped inside the bone by calcification, osteoblasts turn into more mature types of bone cells called osteocytes. Osteoclasts are developed from monocytes or macrophages.

What is Osteoblasts?

What is Osteoblasts?
source: wikipedia.org

Osteoblasts are formed from cells osteoprogenitor which has differentiated. In the osteoblasts are receptors of estrogen and also calcitriol. Osteoblasts have a diameter between 20 to 30 μm and seen very clearly in the surrounding layer of osteoid where bone newly formed.

Osteoblast plasma membrane has nature is typical that the rich will be the enzyme alkaline fostatase, whose concentration in the serum is used as an index of the formation of bone.

Cell osteoblasts that have matured have a lot of apparatus of the Golgi are growing with good which serves as a cell secretory, the cytoplasm is basophilic, and many once reticulum endoplasmic.

Osteoblasts are cells that form a cube or columnar in a state of activity while the state is not active osteoblasts will form lamellar ( Kierszenbaum 2002). Osteoblasts derived from cells pluripotent mesenchymal and save osteoid, the matrix organic that do not mineralize the bone.

source: wikipedia.org

Osteoblasts function to initiate and control the osteoid mineralization process ( Kierszenbaum 2002).

Osteoblasts produce growth factors along with morphogenetic bone proteins.

Osteoblasts play a role in protein synthesis, glycosylation, and secretion producing collagen type I (90% of total protein), osteocalcin, non- collagen proteins including osteonectin, osteopontin, bone sialoprotein, bone growth factors, cytokines, and of course receptors from hormones ( hormones ) Kierszenbaum 2002).

Osteocalcin is a protein secretory specific that arise only at the end of the differentiation of osteoblasts in under the influence of Cbfa1 ( core-binding factor) ( Kierszenbaum 2002).

Osteocalcin many are on protein nonkolagen serves to regulate crystal apetit growth and bind to hydroxyapatite. Osteonectin is a single chain polypeptide that is present in several tissues because it is present at the beginning of bone development. Osteonectin is formed due to osteoblast adhesion which binds to hydroxyapatite.

Sialoprotein bone is a polypeptide chain of sole on the bone and tissue connective mineralized functioning bind cells via binding integrins and hydroxyapatite (Meyer and Wiesmann 2006).

What is Osteoclasts?

What is Osteoclasts?
source: wikipedia.org

Osteoclasts are giant cells of fused monocytes (a type of white blood cell ) that are concentrated in the endosteum and release lysosomal enzymes to break down proteins and minerals in the extracellular matrix.

Osteoclasts have different progenitors from other bone cells because they do not originate from mesenchymal cells, but rather from myeloid tissue, namely monocytes or macrophages in bone marrow ( Ott 2002).

Osteoclasts are similar to other phagocytic cells and play an active role in the process of bone resorption. Osteoclasts are cells fusion of some of monocytes that are multinuclear (10-20 nuclei ) with a size large and is located in the bone cortical or bone trabecular.

source: wikipedia.org

Osteoclast function in the mechanism of osteoclastogenesis, activation of resorption of calcium bone, and cartilage, and respond to hormonal which can degrade the structure and function of bone. Osteoclasts in the process of bone resorption secrete enzymes of collagenase and other proteinases, lactic acid, and citric acid which can dissolve bone matrix.

The enzymes of this break down or dissolving matrix organic bone while the acid will dissolve the salts bone.

Through the process of resorption of bone, osteoclasts participate affect some processes in the body that is in maintaining the balance of calcium blood, growth and development of bone and repair bone after experiencing a fracture (Derek et al. 2007).

Osteoclast activity is influenced by the hormone cytokinin. Osteoclasts have receptors for calcitokinin , which is a thyroid hormone. Will but osteoblasts have receptors for the hormone parathyroid and so activated by the hormone is, osteoblasts will produce a cytokine which is called factor stimulating osteoclast.

Osteoclasts along hormone parathyroid play a role in setting the levels of calcium blood that made the target of the treatment of osteoporosis ( Junqueira and Carneiro 2005; Tortora and Derrickson 2009).

Similarities between Osteoblasts and Osteoclasts

  • Osteoblasts and osteoclasts are two types of cells are found in bone.
  • Osteoblasts and osteoclasts are involved in bone repair and damage.
  • Osteoblasts and osteoclasts are found on bone surfaces.

Difference Between Osteoblasts and Osteoclasts

Difference Between Osteoblasts and Osteoclasts


Osteoblasts: Osteoblasts are cells forming bone are derived from cells osteoprogenitor mesenchymal and involved in the process of remodeling bone.

Osteoclasts: Osteoclasts are a type of cells of bone that are responsible for the resorption of bone.

Developed from

Osteoblasts: Osteoblasts are developed from osteogenic cells.

Osteoclasts: Osteoclasts are developed from monocytes or macrophages.

Cell Size

Osteoblasts: Osteoblasts are cells that are small and not cored.

Osteoclasts: Cells osteoclasts large, the cell nuclei much.


Osteoblasts: Osteoblasts are involved in bone formation and mineralization.

Osteoclasts: Osteoclasts are involved in bone breakdown and bone resorption.

Osteoblasts vs Osteoclasts

  • Osteoblasts mediate osteoclast activity by releasing cytokines.
  • Osteoblasts have receptors for parathyroid hormone, while osteoclasts do not.
  • Osteoblasts promote bone formation while osteoclasts promote bone damage.
  • Osteoblasts become osteocytes but osteoclasts do not.
  • Osteoblasts more small and mononucleate, while osteoclasts were more large and multinucleate.


Osteoblasts and osteoclasts are two types of cells are found in bone, to work in the remodeling of bone. Osteoblasts are developed from osteogenic cells while osteoclasts are developed from monocytes or macrophages. Osteoblasts are the cells that are involved in the formation of bone and mineralization of bone.

Osteoclasts are cells that are involved in the breakdown and resorption of bone. Because it is, the difference main between osteoblasts and osteoclasts is a function of each type of cell bone in remodeling bone.

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